2018

Cimorelli, M.; Brett, A.; Fafarman, A.; Kohut, A.; Andrien, B.; Barrett, K.; Wrenn, S. Introducing a nested phase change agent with an acoustic response that depends on electric field: A candidate for myocardial perfusion imaging and drug delivery. Applied Acoustics 2018, 138. 10.1016/j.apacoust.2018.03.028.

2017

Nguyena, A.T.; Sunnya, Y.; Bawieca, C.; Lewina, P.A.; Wrenn, S.P. Investigating the spatial extent of acoustically activated echogenic liposomes. Ultrasonics 2017, 77, 176–182.

2016

Sundaram, R.V.K.; Li, H.; Bailey, L.; Rashad, B.B.; Aneja, R.; Weiss, K.; Huynh, J.; Bastian, A.R.; Papazoglou, E.; Abrams, C.F.; Wrenn, S.; Chaiken, I. Impact of HIV-1 Membrane Cholesterol on Cell-Independent Lytic Inactivation and Cellular Infectivity. Biochemistry 2016, 55:447-458 (10.1021/acs.biochem.5b00936).

2015

Nguyen, A. T.; Lewin, P. A.; Wrenn, S. P. Hydrophobic drug concentration affects the acoustic susceptibility of liposomes. Biochim. Biophys. Acta, Gen. Subj. 2015, 1850(4), 667-672.

Wallace, N.; Dicker, S.; Lewin, P; et al. Inertial cavitation threshold of nested microbubbles. Ultrasonics 2015, 58, 67-74.

Wallace, N.; Wrenn, S. P. Ultrasound triggered drug delivery with liposomal nested microbubbles. Ultrasonics 2015, 63, 31-38.

2014

Nguyen, A. T.; Wrenn, S. P. Acoustically active liposome-nanobubble complexes for enhanced ultrasonic imaging and ultrasound- triggered drug delivery. Wiley Interdiscip. Rev. Nanomed. Nanobiotechnol. 2014, 6 (3), 316-325.

Wallace, N.; Dicker, S.; Lewin, P.; et al. Influence of nesting shell size on brightness longevity and resistance to ultrasound-induced dissolution during enhanced B-mode contrast imaging. Ultrasonics 2014, 54(8), 2099-2108.

2013

Brown, A. C.; Wrenn, S. P. Nanoscale Phase Separation in DSPC-Cholesterol Systems. Langmuir 2013, 29(31), 9832-9840.

Dicker, S.; Mleczko, M.; Schmitz, G.; Wrenn, S.P. Size distribution of microbubbles as a function of shell composition. Ultrasonics 2013, 53(7), 1363-1367.

Dicker, S.; Mleczko, M.; Siepmann, M.; Wallace, N.; Sunny, Y.; Bawiec, C.R.; Schmitz, G.; Lewin, P.; Wrenn, S.P. Influence of Shell Composition on the Resonance Frequency of Microbubble Contrast Agents. Ultrasound Med. Biol. 2013, 39(7), 1292-1302.

Wrenn, S.P.; Small, E.; Dan, N. Bubble nucleation in lipid bilayers: A mechanism for low frequency ultrasound disruption. Biochim. Biophys. Acta, Biomembr. 2013, 1828(4), 1192-1197.

2012

Mleczko, M.; Dicker, S.M.; Wrenn, S.P.; Schmitz, G. Influence of Microbubble Shell Chemistry on the Destruction Threshold of Ultrasound Contrast Agent Microbubbles. Acoust. Imaging 2012, 31, 91-101.

Small, E. F.; Dan, N. R.; Wrenn, S. P. Low-Frequency Ultrasound-Induced Transport across Non-Raft-Forming Ternary Lipid Bilayers. Langmuir 2012, 28, 14364-14372.

Wrenn, S.P.; Dicker, S.M.; Maghnouj, A.; Hahn, S.A.; Mleczko, M.; Hensel, K.; Schmitz, G. Microcapsules: Reverse Sonoporation and Long-lasting, Safe Contrast. Acoust. Imaging 2012, 31, 81-90.

Wrenn, S.P.; Dicker, S.M.; Small, E.F.; Dan, N.R.; Mleczko, M.; Schmitz, G.; Lewin, P.A. Bursting bubbles and bilayers. Theranostics, In press.

2011

Dicker, S.; Mleczko, M.; Hensel, K.; Schmitz, G.; Bartolomeo, A.; Wrenn. S.P. Coencapsulation of lipid microbubbles within polymer microcapsules for contrast applications. Bubble Science Technology & Engineering 2011, 3, 12-19.

Small, E.F.; Willy, M.C.; Lewin, P.A.; Wrenn, S.P. Ultrasound-induced transport across lipid bilayers: Influence of phase behavior. Colloid Surface A 2011, 390(1-3), 40-47.

Walters, M. J.; Wrenn, S. P. Mechanistic roles of lipoprotein lipase and sphingomyelinase in low density lipoprotein aggregation. J. Colloid Interface Sci. 2011, 363 (1), 268-274.

Wrenn, S.P.; Dicker, S.; Small, E.F.; Maghnouj, M.; Hahn, S.A.; Mleczko, M.; Hensel, K.; Schmitz, G. MICROCAPSULES: Reverse Sonoporation and Long-lasting, Safe Contrast. AI31 Proceedings, 2011.

2010

Dicker, S.; Mleczko, M.; Schmitz, G.; Wrenn. S.P. Determination of microbubble cavitation threshold pressure as function of shell chemistry. Bubble Science, Engineering & Technology 2010, 2, 55-64.

*Mleczko, M.; Dicker, S.; Schmitz, G. Wrenn, S.P. Determination of the inertial cavitation threshold of ultrasound contrast agents. Proc. BMT, Rostock, Germany, 2010.

Walters, M.J.; Wrenn, S.P. Size-selective uptake of colloidal low density lipoprotein aggregates by cultured white blood cells. J. Colloid Interface Sci. 2010, 350(2) 494-501.

2009

Boesze-Battaglia, K.; Brown, A.; Walker, L.;, Besack, D.; Zekavat, A.; Wrenn, S.P; Krummenacher, C.; Shenker, B.J. Cytolethal Distending Toxin-induced Cell Cycle Arrest of Lymphocytes Is Dependent upon Recognition and Binding to Cholesterol. J Biol Chem. 2009, 284(16), 10650-8.

Brown, A.C.; Wrenn, S.P.; Suresh, N.; et al. Phospholipid-Stabilized Microbubbles: Influence of Shell Chemistry on Cavitation Threshold and Binding to Giant Uni-Lamellar Vesicles. J. Membr. Biol. 2009, 232, 1-3, 35-45.

Wrenn, S.P.; Dicker, S.; Small, E.F.; Mleczko, M. Controlling Cavitation for Controlled Release. Proc. IEEE Int. Ultrason. Symp. 2009, 104-107.

Wrenn S.P.; Mleckzko M.; Schmitz G. Phospholipid-Stabilized Microbubbles: Influence of Shell Chemistry on Cavitation Threshold and Binding to Giant Uni-Lamellar Vesicles. Appl. Acoust. 2009, 70, 10, 1313-1322.

2008

M.J. Walters, S.P. Wrenn. "Effect of Sphingomyelinase-Mediated Generation of Ceramide on Aggregation of Low Density Lipoprotein." Langmuir 2008 In Press.

2007

A.C. Brown, K.B.Towles, S.P. Wrenn, "Measuring raft size as a function of membrane composition in PC-based systems:Part I- Binary systems," Langmuir 2007 Vol. 23, No. 22, pp. 11180 -11187.

K. B. Towles, A. C. Brown, S. P. Wrenn, N. Dan, "Effect of membrane microheterogeneity and domain size on fluorescence resonance energy transfer," Biophys. J, Vol. 93 pp. 655-667 (2007).

A.C. Brown, K.B.Towles, S.P. Wrenn, "Measuring raft size as a function of membrane composition in PC-based systems:Part II- Ternary Systems," Langmuir 2007 Vol. 23, No. 22, pp. 11188-11196.

2006

Mona Pong, Sumet Umchid, A.J. Guarino, P.A. Lewin, Jerzy Litniewski, Andrzej Nowicki and S.P. Wrenn, "In vitro ultrasound-mediated leakage from phospholipid vesicles," Ultrasonics, Vol. 45, No.1-4, Dec. 2006, pp.133-145.

A.J. Guarino, T. Tulenko, and S.P. Wrenn . "Interactions between sphingomyelin and cholesterol in low density lipoproteins and model membranes." J. Coll. Int. Sci, 2006, 293, 203-212.

A.J. Guarino, T. Tulenko and S.P. Wrenn, "Sphingomyelinase-to-LDL molar ratio determines low density lipoprotein aggregation size: biological significance," Chemistry and Physics of Lipids, Vol. 142, No. 1-2, Jul. 2006, pp. 33-42.

Troup, G.M.; Wrenn, S.P.; Apel-Paz, M.; Doncel, G.F.; Vanderlick, T.K. A Time-resolved diphenylhexatriene (DPH) anisotropy characterization of a series of model lipid constructs for the sperm plasma membrane. Industrial and Engineering Chemistry Research 2006, 45(21), 6939-6945.

2005

M.V. Gudheti, S.P. Lee, D. Dganino, and S.P. Wrenn (2005). "Combined Interaction of Phospholipase C and Apolipoprotein A-I with Small, Unilamellar Lecithin-Cholesterol Vesicles: Influence of Apolipoprotein A-I Concentration and Vesicle Composition," Biochemistry, Vol. 44, No.19, pp. 7294-7304.

*Virmani, R.; Kolodgie, F.; Burke, A.; Finn, A.; Gold, H.; Tulenko, T.; Wrenn, S.P.; Narula, J. Atherosclerotic Plaque Progression and Vulnerability to Rupture: Angiogenesis as a Source of Intraplaque Hemorrhage. Arterioscler. Thromb. Vasc. Biol. 2005, 25, 2054-2061.

2004

G. M. Troup, S.P. Wrenn, "Temperature and cholesterol composition-dependent behavior of 1-myristoyl-2-[12-[(5-dimethylamino-1-naphthalenesulfonyl)amino]dodecanoyl]-sn-glycero-3-phosphocholine in 1,2-dimyristoyl-sn-glycero-3-phosphocholine membranes," Chemistry and Physics of Lipids, Vol.131, No. 2, Sep. 2004, pp. 167-182.

A.J. Guarino, T. N. Tulenko, and S.P.Wrenn . "Cholesterol Crystal Nucleation from Enzymatically-Modified Low Density Lipoproteins: Combined Effect of Sphingomyelinase and Cholesterol Esterase," Biochemistry, Vol. 43, No. 6, Feb.2004, pp.1685-1693.

A.J. Guarino, T. N. Tulenko, and S.P.Wrenn (2004). "Aggregation Kinetics of Low Density Lipoproteins upon Exposure to Sphingomyelinase," J. Colloid. Interface Sci., Vol. 279 , No. 1, pp. 109-116.

G.M. Troup, T.N. Tulenko, S.P. Lee, and S.P.Wrenn (2004). "Estimating the Size of Laterally Phase Separated Domains in Model Membranes with Förster Resonance Energy Transfer: A Simulation Study," Coll Surf. B: Biointerfaces, Vol. 33, No.1, pp.57-65.

2003

Gudheti, M.V., and Wrenn, S.P. "Action of apolipoprotein A-I on lecithin-cholesterol vesicles in model bile", IEEE Proceedings of the Northeast Bioengineering Conference, (2003).

M.Gudheti, Y.I. Gonzalez, S. P. Lee, S.P. Wrenn, "Interaction of apolipoprotein A-I with lecithin-cholesterol vesicles in the presence of phospholipase C," Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids, Vol.1635, No. 2-3, Dec.2003, pp.127-141.

G.M. Troup, T.Tulenko, S.P. Lee, S.P. Wrenn, "Detection and characterization of laterally phase separated cholesterol domains in model lipid membranes," Colloids and Surfaces B: Biointerfaces, Vol.29, No.2-3, Jun.2003, pp.217-231.

2001

Wrenn, S.P.; Gudheti, M.V.; Veleva, A.N.; Lee, S.P.; Kaler, E.W. Characterization of Model Bile Using Fluorescence Energy Transfer from Dehydroergosterol to Dansylated Lecithin. J. Lipid Res. 2001, 42(6), 923-934.

Yoshida, T.; Klinkspoor, J.H.; Kuver, R.; Poot, M.; Rabinovitch, P.S.; Wrenn, S.P.; Kaler, E.W.; Lee, S.P. Effects of bile salts on cholestan-3b,5a,6b-triol-induced apoptosis in dog gallbladder epithelial cells. Biochim. Biophys. Acta- Molecular and Cell Biology of Lipids 2001, 1530(2-3), 199-208.

2000

Yoshida, T.; Klinkspoor, J.H.; Kuver, R.; Wrenn, S.P.; Kaler, E.W.; Lee, S.P. Cholestan-3b, 5a, 6b-triol, but not 7-ketocholesterol, suppresses taurocholate-induced mucin secretion by cultured dog gallbladder epithelial cells. FEBS Letters 2000, 478(1-2), 113-118.

Wrenn, S.P; Lusvardi, V.S.; Whitmyre, G.; Buttrey, D.J. Vapor-Liquid Equilibria in the Undergraduate Laboratory. CEE. 2000, 34(1), 74-85.

1999

Wrenn, S.P.; Lee, S.P.; Kaler, E.W. A fluorescence energy transfer study of lecithin-cholesterol vesicles in the presence of phospholipase C. J. Lipid Res. 1999, 40(8), 1483-1494.